Assay Detail
Binding
CHEMBL859660
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MCD
56
Total Activities
56
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Malonyl-CoA decarboxylase, mitochondrial (CHEMBL4698) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and structure-activity relationship of small-molecule malonyl coenzyme A decarboxylase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 56 | 7.29 | 10.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL205986 | — | — | 1 | 10.15 |
| CHEMBL380487 | — | — | 1 | 9.54 |
| CHEMBL205506 | — | — | 1 | 9.07 |
| CHEMBL204287 | — | — | 1 | 9.01 |
| CHEMBL202688 | — | — | 1 | 9.00 |
| CHEMBL206852 | — | — | 1 | 8.94 |
| CHEMBL202689 | — | — | 1 | 8.84 |
| CHEMBL202746 | — | — | 1 | 8.70 |
| CHEMBL203835 | — | — | 1 | 8.58 |
| CHEMBL400455 | — | — | 1 | 8.10 |
| CHEMBL380868 | — | — | 1 | 8.10 |
| CHEMBL206756 | — | — | 1 | 7.85 |
| CHEMBL203790 | — | — | 1 | 7.72 |
| CHEMBL382695 | — | — | 1 | 7.70 |
| CHEMBL206438 | — | — | 1 | 7.70 |
| CHEMBL202632 | — | — | 1 | 7.58 |
| CHEMBL381996 | — | — | 1 | 7.55 |
| CHEMBL202905 | — | — | 1 | 7.52 |
| CHEMBL381564 | — | — | 1 | 7.51 |
| CHEMBL383498 | — | — | 1 | 7.47 |
| CHEMBL205932 | — | — | 1 | 7.47 |
| CHEMBL203991 | — | — | 1 | 7.43 |
| CHEMBL380746 | — | — | 1 | 7.40 |
| CHEMBL383478 | — | — | 1 | 7.39 |
| CHEMBL206562 | — | — | 1 | 7.38 |
| CHEMBL205117 | — | — | 1 | 7.37 |
| CHEMBL382600 | — | — | 1 | 7.23 |
| CHEMBL205462 | — | — | 1 | 7.22 |
| CHEMBL205719 | — | — | 1 | 7.14 |
| CHEMBL205931 | — | — | 1 | 7.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL205986 | — | IC50 | = | 0.07 | nM | 10.15 |
| CHEMBL380487 | — | IC50 | = | 0.29 | nM | 9.54 |
| CHEMBL205506 | — | IC50 | = | 0.85 | nM | 9.07 |
| CHEMBL204287 | — | IC50 | = | 0.98 | nM | 9.01 |
| CHEMBL202688 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL206852 | — | IC50 | = | 1.14 | nM | 8.94 |
| CHEMBL202689 | — | IC50 | = | 1.45 | nM | 8.84 |
| CHEMBL202746 | — | IC50 | = | 1.99 | nM | 8.70 |
| CHEMBL203835 | — | IC50 | = | 2.65 | nM | 8.58 |
| CHEMBL400455 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL380868 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL206756 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL203790 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL206438 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL382695 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL202632 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL381996 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL202905 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL381564 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL383498 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL205932 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL203991 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL380746 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL383478 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL206562 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL205117 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL382600 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL205462 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL205719 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL205931 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL382246 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL204960 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL378375 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL382794 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL203871 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL381580 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL204109 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL381266 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL204273 | — | IC50 | = | 166.0 | nM | 6.78 |
| CHEMBL205016 | — | IC50 | = | 175.0 | nM | 6.76 |
| CHEMBL206808 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL204767 | — | IC50 | = | 199.0 | nM | 6.70 |
| CHEMBL203516 | — | IC50 | = | 247.0 | nM | 6.61 |
| CHEMBL204248 | — | IC50 | = | 269.0 | nM | 6.57 |
| CHEMBL206341 | — | IC50 | = | 321.0 | nM | 6.49 |
| CHEMBL206201 | — | IC50 | = | 376.0 | nM | 6.42 |
| CHEMBL380364 | — | IC50 | = | 394.0 | nM | 6.41 |
| CHEMBL206570 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL203444 | — | IC50 | = | 627.0 | nM | 6.20 |
| CHEMBL427589 | — | IC50 | = | 773.0 | nM | 6.11 |