Assay Detail
Binding
CHEMBL859690
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against recombinant human SIRT2 expressed in Escherichia coli by fluorimetric assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
NAD-dependent protein deacetylase sirtuin-2 (CHEMBL4462) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.96 | 5.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL446446 | — | — | 1 | 5.56 |
| CHEMBL115600 | — | — | 1 | 4.94 |
| CHEMBL420311 | — | — | 1 | 4.71 |
| CHEMBL112265 | — | — | 1 | 4.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL446446 | — | IC50 | = | 2770.0 | nM | 5.56 |
| CHEMBL115600 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL420311 | — | IC50 | = | 19600.0 | nM | 4.71 |
| CHEMBL112265 | — | IC50 | = | 24800.0 | nM | 4.61 |