Assay Detail
Binding
CHEMBL859745
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against human SIRT2
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
NAD-dependent protein deacetylase sirtuin-2 (CHEMBL4462) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.40 | 4.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL372375 | — | — | 1 | 4.59 |
| CHEMBL200762 | — | — | 1 | 4.45 |
| CHEMBL197282 | — | — | 1 | 4.41 |
| CHEMBL198582 | — | — | 1 | 4.31 |
| CHEMBL380797 | SIRTINOL | — | 1 | 4.24 |
| CHEMBL371286 | — | — | 1 | - |
| CHEMBL200731 | — | — | 1 | - |
| CHEMBL383787 | — | — | 1 | - |
| CHEMBL200725 | — | — | 1 | - |
| CHEMBL200544 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL372375 | — | IC50 | = | 25900.0 | nM | 4.59 |
| CHEMBL200762 | — | IC50 | = | 35700.0 | nM | 4.45 |
| CHEMBL197282 | — | IC50 | = | 39400.0 | nM | 4.41 |
| CHEMBL198582 | — | IC50 | = | 49300.0 | nM | 4.31 |
| CHEMBL380797 | SIRTINOL | IC50 | = | 57700.0 | nM | 4.24 |
| CHEMBL371286 | — | IC50 | - | — | - | |
| CHEMBL200731 | — | IC50 | - | — | - | |
| CHEMBL383787 | — | IC50 | - | — | - | |
| CHEMBL200725 | — | IC50 | - | — | - | |
| CHEMBL200544 | — | IC50 | - | — | - |