Assay Detail
Binding
CHEMBL859779
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity for rat 5HT1A receptor
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and SAR of highly potent dual 5-HT1A and 5-HT1B antagonists as potential antidepressant drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 7.72 | 7.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL370110 | — | — | 1 | 7.79 |
| CHEMBL198463 | — | — | 1 | 7.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL370110 | — | Ki | = | 16.3 | nM | 7.79 |
| CHEMBL198463 | — | Ki | = | 23.0 | nM | 7.64 |