Assay Detail
Binding
CHEMBL859798
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anticholinesterase activity against human erythrocyte AChE
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 6.75 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL130458 | TOLSERINE | — | 1 | 8.00 |
| CHEMBL205895 | — | — | 1 | 7.89 |
| CHEMBL464538 | — | — | 1 | 7.75 |
| CHEMBL426674 | — | — | 1 | 7.70 |
| CHEMBL433041 | EPTASTIGMINE | 2.0 | 1 | 7.66 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 7.66 |
| CHEMBL54727 | — | — | 1 | 7.66 |
| CHEMBL205231 | — | — | 1 | 7.57 |
| CHEMBL94 | PHYSOSTIGMINE | 3.0 | 1 | 7.55 |
| CHEMBL206093 | — | — | 1 | 7.44 |
| CHEMBL378404 | — | — | 1 | 7.42 |
| CHEMBL395280 | HUPERZINE A | 2.0 | 1 | 7.33 |
| CHEMBL205940 | — | — | 1 | 7.25 |
| CHEMBL381926 | — | — | 1 | 7.09 |
| CHEMBL205340 | — | — | 1 | 7.03 |
| CHEMBL207777 | — | — | 1 | 7.01 |
| CHEMBL204895 | — | — | 1 | 7.00 |
| CHEMBL205335 | — | — | 1 | 6.85 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.72 |
| CHEMBL377283 | — | — | 1 | 6.31 |
| CHEMBL380830 | — | — | 1 | 6.21 |
| CHEMBL129837 | 4-ISOPROPYLPHENSERINE | — | 1 | 6.12 |
| CHEMBL659 | GALANTAMINE | 4.0 | 1 | 6.10 |
| CHEMBL205967 | — | — | 1 | 5.62 |
| CHEMBL205321 | — | — | 1 | 5.46 |
| CHEMBL382207 | — | — | 1 | 5.41 |
| CHEMBL636 | RIVASTIGMINE | 4.0 | 1 | 5.38 |
| CHEMBL381782 | — | — | 1 | 5.26 |
| CHEMBL206237 | — | — | 1 | 5.17 |
| CHEMBL382351 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL130458 | TOLSERINE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL205895 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL464538 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL426674 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL433041 | EPTASTIGMINE | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL502 | DONEPEZIL | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL54727 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL205231 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL94 | PHYSOSTIGMINE | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL206093 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL378404 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL395280 | HUPERZINE A | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL205940 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL381926 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL205340 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL207777 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL204895 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL205335 | — | IC50 | = | 142.0 | nM | 6.85 |
| CHEMBL95 | TACRINE | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL377283 | — | IC50 | = | 486.0 | nM | 6.31 |
| CHEMBL380830 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL129837 | 4-ISOPROPYLPHENSERINE | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL659 | GALANTAMINE | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL205967 | — | IC50 | = | 2420.0 | nM | 5.62 |
| CHEMBL205321 | — | IC50 | = | 3430.0 | nM | 5.46 |
| CHEMBL382207 | — | IC50 | = | 3860.0 | nM | 5.41 |
| CHEMBL636 | RIVASTIGMINE | IC50 | = | 4150.0 | nM | 5.38 |
| CHEMBL381782 | — | IC50 | = | 5510.0 | nM | 5.26 |
| CHEMBL206237 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL382351 | — | IC50 | = | 9890.0 | nM | 5.00 |
| CHEMBL494887 | TETRAISOPROPYL PYROPHOSPHORAMIDE | IC50 | = | 340000.0 | nM | - |