Assay Detail
Binding
CHEMBL859867
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Average Binding Constant for EGFR; NA=Not Active at 10 uM
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
A small molecule-kinase interaction map for clinical kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 20 | 7.72 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL607707 | PELITINIB | 2.0 | 1 | 9.00 |
| CHEMBL31965 | CANERTINIB | 3.0 | 1 | 8.85 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 8.85 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 8.74 |
| CHEMBL554 | LAPATINIB | 4.0 | 1 | 8.26 |
| CHEMBL24828 | VANDETANIB | 4.0 | 1 | 7.77 |
| CHEMBL388978 | STAUROSPORINE | — | 1 | 7.16 |
| CHEMBL10 | SB-203580 | — | 1 | 5.54 |
| CHEMBL278041 | SB-202190 | — | 1 | 5.34 |
| CHEMBL124660 | TANDUTINIB | 2.0 | 1 | - |
| CHEMBL91829 | RUBOXISTAURIN | 3.0 | 1 | - |
| CHEMBL101253 | VATALANIB | 3.0 | 1 | - |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | - |
| CHEMBL941 | IMATINIB | 4.0 | 1 | - |
| CHEMBL1725279 | SP-600125 | — | 1 | - |
| CHEMBL103667 | DORAMAPIMOD | 2.0 | 1 | - |
| CHEMBL119385 | NEFLAMAPIMOD | 2.0 | 1 | - |
| CHEMBL535 | SUNITINIB | 4.0 | 1 | - |
| CHEMBL14762 | SELICICLIB | 2.0 | 1 | - |
| CHEMBL428690 | ALVOCIDIB | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL607707 | PELITINIB | Kd | = | 1.0 | nM | 9.00 |
| CHEMBL31965 | CANERTINIB | Kd | = | 1.4 | nM | 8.85 |
| CHEMBL553 | ERLOTINIB | Kd | = | 1.4 | nM | 8.85 |
| CHEMBL939 | GEFITINIB | Kd | = | 1.8 | nM | 8.74 |
| CHEMBL554 | LAPATINIB | Kd | = | 5.5 | nM | 8.26 |
| CHEMBL24828 | VANDETANIB | Kd | = | 17.0 | nM | 7.77 |
| CHEMBL388978 | STAUROSPORINE | Kd | = | 70.0 | nM | 7.16 |
| CHEMBL10 | SB-203580 | Kd | = | 2900.0 | nM | 5.54 |
| CHEMBL278041 | SB-202190 | Kd | = | 4600.0 | nM | 5.34 |
| CHEMBL124660 | TANDUTINIB | Kd | - | — | - | |
| CHEMBL91829 | RUBOXISTAURIN | Kd | - | — | - | |
| CHEMBL101253 | VATALANIB | Kd | - | — | - | |
| CHEMBL1336 | SORAFENIB | Kd | - | — | - | |
| CHEMBL941 | IMATINIB | Kd | - | — | - | |
| CHEMBL1725279 | SP-600125 | Kd | - | — | - | |
| CHEMBL103667 | DORAMAPIMOD | Kd | - | — | - | |
| CHEMBL119385 | NEFLAMAPIMOD | Kd | - | — | - | |
| CHEMBL535 | SUNITINIB | Kd | - | — | - | |
| CHEMBL14762 | SELICICLIB | Kd | - | — | - | |
| CHEMBL428690 | ALVOCIDIB | Kd | - | — | - |