Assay Detail
Binding
CHEMBL859877
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against IKK1
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHEMBL3476) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and preparation of 2-benzamido-pyrimidines as inhibitors of IKK.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.20 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL199837 | — | — | 1 | 7.52 |
| CHEMBL382945 | — | — | 1 | 7.52 |
| CHEMBL372736 | — | — | 1 | 7.00 |
| CHEMBL200229 | — | — | 1 | 6.82 |
| CHEMBL200027 | — | — | 1 | 6.70 |
| CHEMBL199980 | — | — | 1 | 6.40 |
| CHEMBL381041 | — | — | 1 | 6.30 |
| CHEMBL200106 | — | — | 1 | 6.30 |
| CHEMBL371543 | — | — | 1 | 6.16 |
| CHEMBL200462 | — | — | 1 | 6.00 |
| CHEMBL371967 | — | — | 1 | 5.92 |
| CHEMBL200832 | — | — | 1 | 5.92 |
| CHEMBL370166 | — | — | 1 | 5.43 |
| CHEMBL382752 | — | — | 1 | 5.42 |
| CHEMBL200946 | — | — | 1 | 5.30 |
| CHEMBL372160 | — | — | 1 | 4.52 |
| CHEMBL372345 | — | — | 1 | - |
| CHEMBL200892 | — | — | 1 | - |
| CHEMBL200860 | — | — | 1 | - |
| CHEMBL200191 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL199837 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL382945 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL372736 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL200229 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL200027 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL199980 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL381041 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL200106 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL371543 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL200462 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL371967 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL200832 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL370166 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL382752 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL200946 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL372160 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL372345 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL200892 | — | IC50 | - | — | - | |
| CHEMBL200860 | — | IC50 | - | — | - | |
| CHEMBL200191 | — | IC50 | - | — | - |