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Assay Detail

CHEMBL859919

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to human factor 10a
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Coagulation factor X (CHEMBL244)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Aminobenzisoxazoles with biaryl P4 moieties as potent, selective, and orally bioavailable factor Xa inhibitors.
Quan ML, Han Q, Fevig JM, Lam PY, Bai S, Knabb RM, Luettgen JM, Wong PC, Wexler RR.
Bioorg Med Chem Lett (2006) 16 : 1795 -1798
PubMed 16434195 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 23 9.57 10.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL380431 1 10.70
CHEMBL205383 1 10.30
CHEMBL263252 1 10.10
CHEMBL379036 1 10.00
CHEMBL204416 1 9.82
CHEMBL436766 1 9.80
CHEMBL206335 RAZAXABAN 2.0 1 9.72
CHEMBL380617 1 9.70
CHEMBL382339 1 9.70
CHEMBL381949 1 9.68
CHEMBL380356 1 9.60
CHEMBL204994 1 9.57
CHEMBL380618 1 9.52
CHEMBL205187 1 9.47
CHEMBL426313 1 9.40
CHEMBL381836 1 9.28
CHEMBL380430 1 9.28
CHEMBL205288 1 9.27
CHEMBL407942 1 9.26
CHEMBL382559 1 9.18
CHEMBL205653 1 9.07
CHEMBL380829 1 8.94
CHEMBL381316 1 8.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL380431 Ki = 0.02 nM 10.70
CHEMBL205383 Ki = 0.05 nM 10.30
CHEMBL263252 Ki = 0.08 nM 10.10
CHEMBL379036 Ki = 0.1 nM 10.00
CHEMBL204416 Ki = 0.15 nM 9.82
CHEMBL436766 Ki = 0.16 nM 9.80
CHEMBL206335 RAZAXABAN Ki = 0.19 nM 9.72
CHEMBL380617 Ki = 0.2 nM 9.70
CHEMBL382339 Ki = 0.2 nM 9.70
CHEMBL381949 Ki = 0.21 nM 9.68
CHEMBL380356 Ki = 0.25 nM 9.60
CHEMBL204994 Ki = 0.27 nM 9.57
CHEMBL380618 Ki = 0.3 nM 9.52
CHEMBL205187 Ki = 0.34 nM 9.47
CHEMBL426313 Ki = 0.4 nM 9.40
CHEMBL381836 Ki = 0.53 nM 9.28
CHEMBL380430 Ki = 0.52 nM 9.28
CHEMBL205288 Ki = 0.54 nM 9.27
CHEMBL407942 Ki = 0.55 nM 9.26
CHEMBL382559 Ki = 0.66 nM 9.18
CHEMBL205653 Ki = 0.86 nM 9.07
CHEMBL380829 Ki = 1.14 nM 8.94
CHEMBL381316 Ki = 2.0 nM 8.70