Assay Detail
Binding
CHEMBL859948
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Binding affinity to rabbit factor 10a
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Aminobenzisoxazoles with biaryl P4 moieties as potent, selective, and orally bioavailable factor Xa inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 9.62 | 9.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL436766 | — | — | 1 | 9.77 |
| CHEMBL206335 | RAZAXABAN | 2.0 | 1 | 9.72 |
| CHEMBL381949 | — | — | 1 | 9.66 |
| CHEMBL379036 | — | — | 1 | 9.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL436766 | — | Ki | = | 0.17 | nM | 9.77 |
| CHEMBL206335 | RAZAXABAN | Ki | = | 0.19 | nM | 9.72 |
| CHEMBL381949 | — | Ki | = | 0.22 | nM | 9.66 |
| CHEMBL379036 | — | Ki | = | 0.46 | nM | 9.34 |