Assay Detail
Binding
CHEMBL859957
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [11C](R)-PK1119 from Sprague-Dawley rat brain PBR
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
[2-11C]isopropyl-, [1-11C]ethyl-, and [11C]methyl-labeled phenoxyphenyl acetamide derivatives as positron emission tomography ligands for the peripheral benzodiazepine receptor: radiosynthesis, uptake, and in vivo binding in brain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 9.83 | 10.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL205971 | — | — | 1 | 10.13 |
| CHEMBL63064 | — | — | 1 | 10.02 |
| CHEMBL381602 | — | — | 1 | 10.01 |
| CHEMBL205767 | — | — | 1 | 9.72 |
| CHEMBL481537 | PK-11195 | — | 1 | 9.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL205971 | — | Ki | = | 0.074 | nM | 10.13 |
| CHEMBL63064 | — | Ki | = | 0.095 | nM | 10.02 |
| CHEMBL381602 | — | Ki | = | 0.098 | nM | 10.01 |
| CHEMBL205767 | — | Ki | = | 0.19 | nM | 9.72 |
| CHEMBL481537 | PK-11195 | Ki | = | 0.54 | nM | 9.27 |