Assay Detail
Binding
CHEMBL860083
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]colchicine from tubulin by scintillation proximity assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Novel combretastatin analogues endowed with antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.48 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 7.89 |
| CHEMBL210806 | — | — | 1 | 5.94 |
| CHEMBL210722 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 12.9 | nM | 7.89 |
| CHEMBL210806 | — | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL210722 | — | IC50 | = | 2500.0 | nM | 5.60 |