Assay Detail
Functional
CHEMBL860089
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Antiproliferative activity against human HCT116 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel combretastatin analogues endowed with antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.03 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.72 |
| CHEMBL378110 | — | — | 1 | 7.80 |
| CHEMBL210722 | — | — | 1 | 7.27 |
| CHEMBL210806 | — | — | 1 | 7.08 |
| CHEMBL379473 | — | — | 1 | 5.78 |
| CHEMBL382453 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL378110 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL210722 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL210806 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL379473 | — | IC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL382453 | — | IC50 | = | 3000.0 | nM | 5.52 |