Assay Detail
Binding
CHEMBL860161
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]R-PIA or [3H]CGS 21680 from human adenosine A1 receptor in CHO cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Semi-rational design of (north)-methanocarba nucleosides as dual acting A(1) and A(3) adenosine receptor agonists: novel prototypes for cardioprotection.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.28 | 9.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | — | 1 | 9.35 |
| CHEMBL176551 | — | — | 1 | 9.32 |
| CHEMBL284969 | — | — | 1 | 9.08 |
| CHEMBL573937 | — | — | 1 | 7.74 |
| CHEMBL2112177 | — | — | 1 | 7.47 |
| CHEMBL2112178 | — | — | 1 | 6.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | Ki | = | 0.45 | nM | 9.35 |
| CHEMBL176551 | — | Ki | = | 0.48 | nM | 9.32 |
| CHEMBL284969 | — | Ki | = | 0.83 | nM | 9.08 |
| CHEMBL573937 | — | Ki | = | 18.3 | nM | 7.74 |
| CHEMBL2112177 | — | Ki | = | 34.1 | nM | 7.47 |
| CHEMBL2112178 | — | Ki | = | 190.0 | nM | 6.72 |