Assay Detail
Binding
CHEMBL860330
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Inhibitory activity against p38
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Inhibition of Tpl2 kinase and TNF-alpha production with 1,7-naphthyridine-3-carbonitriles: synthesis and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.38 | 4.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL199210 | — | — | 1 | 4.51 |
| CHEMBL197538 | — | — | 1 | 4.24 |
| CHEMBL200381 | — | — | 1 | - |
| CHEMBL371095 | — | — | 1 | - |
| CHEMBL371658 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL199210 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL197538 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL200381 | — | IC50 | = | 180000.0 | nM | - |
| CHEMBL371095 | — | IC50 | > | 400000.0 | nM | - |
| CHEMBL371658 | — | IC50 | > | 400000.0 | nM | - |