Assay Detail
Binding
CHEMBL860398
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against MEK
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Dual specificity mitogen-activated protein kinase kinase 1 (CHEMBL3587) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibition of Tpl2 kinase and TNF-alpha production with 1,7-naphthyridine-3-carbonitriles: synthesis and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.79 | 6.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL371658 | — | — | 1 | 6.20 |
| CHEMBL371095 | — | — | 1 | 6.10 |
| CHEMBL199210 | — | — | 1 | 6.02 |
| CHEMBL197538 | — | — | 1 | 4.82 |
| CHEMBL200381 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL371658 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL371095 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL199210 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL197538 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL200381 | — | IC50 | > | 40000.0 | nM | - |