Assay Detail
Binding
CHEMBL860417
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to thrombin
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-based design of novel groups for use in the P1 position of thrombin inhibitor scaffolds. Part 1: Weakly basic azoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 7.33 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL200153 | — | — | 1 | 9.00 |
| CHEMBL200573 | — | — | 1 | 8.70 |
| CHEMBL115643 | — | — | 1 | 8.34 |
| CHEMBL200134 | — | — | 1 | 8.22 |
| CHEMBL200960 | — | — | 1 | 8.19 |
| CHEMBL373260 | — | — | 1 | 8.10 |
| CHEMBL371650 | — | — | 1 | 8.00 |
| CHEMBL96502 | — | — | 1 | 7.89 |
| CHEMBL371769 | — | — | 1 | 7.77 |
| CHEMBL414853 | — | — | 1 | 7.66 |
| CHEMBL199609 | — | — | 1 | 7.52 |
| CHEMBL200857 | — | — | 1 | 7.47 |
| CHEMBL200959 | — | — | 1 | 7.28 |
| CHEMBL370557 | — | — | 1 | 7.19 |
| CHEMBL200593 | — | — | 1 | 6.84 |
| CHEMBL200110 | — | — | 1 | 6.77 |
| CHEMBL200674 | — | — | 1 | 6.71 |
| CHEMBL199696 | — | — | 1 | 6.70 |
| CHEMBL381205 | — | — | 1 | 6.70 |
| CHEMBL199675 | — | — | 1 | 6.46 |
| CHEMBL265363 | — | — | 1 | 6.42 |
| CHEMBL200520 | — | — | 1 | 6.35 |
| CHEMBL200920 | — | — | 1 | 5.96 |
| CHEMBL200504 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL200153 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL200573 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL115643 | — | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL200134 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL200960 | — | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL373260 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL371650 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL96502 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL371769 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL414853 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL199609 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL200857 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL200959 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL370557 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL200593 | — | Ki | = | 143.0 | nM | 6.84 |
| CHEMBL200110 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL200674 | — | Ki | = | 193.0 | nM | 6.71 |
| CHEMBL199696 | — | Ki | = | 198.0 | nM | 6.70 |
| CHEMBL381205 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL199675 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL265363 | — | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL200520 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL200920 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL200504 | — | Ki | = | 1800.0 | nM | 5.75 |