Assay Detail
Functional
CHEMBL860432
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Inhibition of LPS-induced TNFalpha production in primary human monocytes
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Inhibition of Tpl2 kinase and TNF-alpha production with 1,7-naphthyridine-3-carbonitriles: synthesis and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.81 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL200381 | — | — | 1 | 6.16 |
| CHEMBL371658 | — | — | 1 | 6.10 |
| CHEMBL371095 | — | — | 1 | 5.85 |
| CHEMBL199210 | — | — | 1 | 5.57 |
| CHEMBL197538 | — | — | 1 | 5.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL200381 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL371658 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL371095 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL199210 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL197538 | — | IC50 | = | 4500.0 | nM | 5.35 |