Assay Detail
Binding
CHEMBL860441
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]spiperone from cloned human dopamine D4.2 receptor in HEK298 cells
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK298 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
N-[(3S)-1-benzylpyrrolidin-3-yl]-(2-thienyl)benzamides: human dopamine D4 ligands with high affinity for the 5-HT2A receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 7.94 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL361035 | — | — | 1 | 8.82 |
| CHEMBL83894 | FANANSERIN | 2.0 | 1 | 8.54 |
| CHEMBL360424 | — | — | 1 | 8.52 |
| CHEMBL381019 | — | — | 1 | 8.40 |
| CHEMBL370823 | — | — | 1 | 8.30 |
| CHEMBL197225 | — | — | 1 | 8.15 |
| CHEMBL370134 | — | — | 1 | 7.85 |
| CHEMBL427555 | — | — | 1 | 7.85 |
| CHEMBL198580 | — | — | 1 | 7.85 |
| CHEMBL199186 | — | — | 1 | 7.82 |
| CHEMBL197381 | — | — | 1 | 7.80 |
| CHEMBL370652 | — | — | 1 | 7.68 |
| CHEMBL372770 | — | — | 1 | 7.66 |
| CHEMBL196866 | — | — | 1 | 7.48 |
| CHEMBL373032 | — | — | 1 | 7.28 |
| CHEMBL383383 | — | — | 1 | 7.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL361035 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL83894 | FANANSERIN | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL360424 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL381019 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL370823 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL197225 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL370134 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL427555 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL198580 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL199186 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL197381 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL370652 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL372770 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL196866 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL373032 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL383383 | — | Ki | = | 78.0 | nM | 7.11 |