Compound Detail
CHEMBL370652
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Basic Information
| ChEMBL ID | CHEMBL370652 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AWAXPOLEGZALIG-FQEVSTJZSA-N |
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
430.5
MW (Da)
5.44
ALogP
3
HBA
1
HBD
32.3
PSA (Ų)
0.58
QED
1
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 4 meas. best 7.68
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| D(4) dopamine receptor CHEMBL219 | Ki | 7.68 | 7.68 | 21.0 | 1 |
| Adrenergic receptor alpha-1 CHEMBL1907610 | Ki | 6.44 | 6.44 | 360.0 | 1 |
| 5-hydroxytryptamine receptor 2A CHEMBL224 | Ki | 6.13 | 6.13 | 740.0 | 1 |
| D(2) dopamine receptor CHEMBL217 | Ki | 5.89 | 5.89 | 1300.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| D(4) dopamine receptor | Ki | = | 21.0 | nM | 7.68 | Displacement of [3H]spiperone from cloned human dopamine D4.2 receptor in HEK298... | 16168646 |
| Adrenergic receptor alpha-1 | Ki | = | 360.0 | nM | 6.44 | Displacement of 7-methoxy-[3H]prazosin from adrenergic alpha-1 receptor in rat f... | 16168646 |
| 5-hydroxytryptamine receptor 2A | Ki | = | 740.0 | nM | 6.13 | Displacement of [3H]ketanserin from cloned human 5HT2A receptor in HEK298 cells | 16168646 |
| D(2) dopamine receptor | Ki | = | 1300.0 | nM | 5.89 | Displacement of [3H]spiperone from human dopamine D2(short) receptor in rat pitu... | 16168646 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16168646 | 10.1016/j.bmcl.2005.08.051 | D(4) dopamine receptor | 1 |
| 16168646 | 10.1016/j.bmcl.2005.08.051 | 5-hydroxytryptamine receptor 2A | 1 |
| 16168646 | 10.1016/j.bmcl.2005.08.051 | D(2) dopamine receptor | 1 |
| 16168646 | 10.1016/j.bmcl.2005.08.051 | Adrenergic receptor alpha-1 | 1 |
Data from ChEMBL 36 via Core Engine