Assay Detail
Binding
CHEMBL860446
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of 7-methoxy-[3H]prazosin from adrenergic alpha-1 receptor in rat frontal cortex tissue
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Frontal cortex |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
N-[(3S)-1-benzylpyrrolidin-3-yl]-(2-thienyl)benzamides: human dopamine D4 ligands with high affinity for the 5-HT2A receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 5.99 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL381019 | — | — | 1 | 7.10 |
| CHEMBL361035 | — | — | 1 | 6.80 |
| CHEMBL197381 | — | — | 1 | 6.66 |
| CHEMBL370652 | — | — | 1 | 6.44 |
| CHEMBL197225 | — | — | 1 | 6.40 |
| CHEMBL370823 | — | — | 1 | 6.38 |
| CHEMBL427555 | — | — | 1 | 6.04 |
| CHEMBL360424 | — | — | 1 | 5.92 |
| CHEMBL373032 | — | — | 1 | 5.92 |
| CHEMBL199186 | — | — | 1 | 5.30 |
| CHEMBL196866 | — | — | 1 | 5.16 |
| CHEMBL198580 | — | — | 1 | 5.00 |
| CHEMBL383383 | — | — | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL381019 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL361035 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL197381 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL370652 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL197225 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL370823 | — | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL427555 | — | Ki | = | 920.0 | nM | 6.04 |
| CHEMBL360424 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL373032 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL199186 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL196866 | — | Ki | = | 6900.0 | nM | 5.16 |
| CHEMBL198580 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL383383 | — | Ki | = | 16000.0 | nM | 4.80 |