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Assay Detail

CHEMBL860500

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Functional
Antiviral activity against duck HBV in primary duck hepatocytes
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Duck hepatitis B virus
Cell Type Hepatocyte
Confidence 1 — Organism
Curated By Intermediate

Target

Duck hepatitis B virus (CHEMBL613761)
Type ORGANISM
Organism Duck hepatitis B virus

Publication

Effect of various pyrimidines possessing the 1-[(2-hydroxy-1-(hydroxymethyl)ethoxy)methyl] moiety, able to mimic natural 2'-deoxyribose, on wild-type and mutant hepatitis B virus replication.
Kumar R, Semaine W, Johar M, Tyrrell DL, Agrawal B.
J Med Chem (2006) 49 : 3693 -3700
PubMed 16759112 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 18 5.78 7.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL141 LAMIVUDINE 4.0 1 7.40
CHEMBL376946 1 5.52
CHEMBL377998 1 5.40
CHEMBL210736 1 4.79
CHEMBL379062 1 -
CHEMBL210916 1 -
CHEMBL209621 1 -
CHEMBL208654 IODMETACYCLUR 1 -
CHEMBL210951 1 -
CHEMBL210828 1 -
CHEMBL287845 1 -
CHEMBL210664 1 -
CHEMBL207010 1 -
CHEMBL35047 1 -
CHEMBL36394 1 -
CHEMBL379526 1 -
CHEMBL333559 1 -
CHEMBL37840 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL141 LAMIVUDINE EC50 = 40.0 nM 7.40
CHEMBL376946 EC50 = 3000.0 nM 5.52
CHEMBL377998 EC50 = 4000.0 nM 5.40
CHEMBL210736 EC50 = 16200.0 nM 4.79
CHEMBL379062 EC50 > 40400.0 nM -
CHEMBL210916 EC50 > 43200.0 nM -
CHEMBL209621 EC50 > 46000.0 nM -
CHEMBL208654 IODMETACYCLUR EC50 > 28000.0 nM -
CHEMBL210951 EC50 > 43400.0 nM -
CHEMBL210828 EC50 > 32300.0 nM -
CHEMBL287845 EC50 > 42900.0 nM -
CHEMBL210664 EC50 > 38400.0 nM -
CHEMBL207010 EC50 > 41000.0 nM -
CHEMBL35047 EC50 > 43400.0 nM -
CHEMBL36394 EC50 > 43200.0 nM -
CHEMBL379526 EC50 > 38300.0 nM -
CHEMBL333559 EC50 > 42700.0 nM -
CHEMBL37840 EC50 > 33800.0 nM -