Assay Detail
Binding
CHEMBL860512
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]prazosin from alpha-1 adrenergic receptor of porcine cortical membrane
7
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Fancy bioisosteres: novel paracyclophane derivatives as super-affinity dopamine D3 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.74 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL210567 | — | — | 2 | 8.60 |
| CHEMBL25236 | BP-897 | — | 1 | 8.30 |
| CHEMBL208847 | — | — | 1 | 8.08 |
| CHEMBL426863 | — | — | 1 | 7.35 |
| CHEMBL209876 | — | — | 1 | 7.10 |
| CHEMBL210461 | — | — | 1 | 6.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL210567 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL210567 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL25236 | BP-897 | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL208847 | — | Ki | = | 8.4 | nM | 8.08 |
| CHEMBL426863 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL209876 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL210461 | — | Ki | = | 480.0 | nM | 6.32 |