Assay Detail
Functional
CHEMBL860529
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Cowpox virus Brighton replication in HFF cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cowpox virus |
| Cell Type | HFF |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and antiviral evaluation of alkoxyalkyl derivatives of 9-(S)-(3-hydroxy-2-phosphonomethoxypropyl)adenine against cytomegalovirus and orthopoxviruses.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.83 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL203496 | — | — | 1 | 8.15 |
| CHEMBL382196 | — | — | 1 | 7.70 |
| CHEMBL204711 | — | — | 1 | 7.70 |
| CHEMBL381753 | — | — | 1 | 7.47 |
| CHEMBL203321 | BRINCIDOFOVIR | 4.0 | 1 | 7.22 |
| CHEMBL206291 | — | — | 1 | 6.52 |
| CHEMBL286534 | — | — | 1 | 5.40 |
| CHEMBL5314375 | CIDOFOVIR | 4.0 | 1 | 4.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL203496 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL382196 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL204711 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL381753 | — | EC50 | = | 34.0 | nM | 7.47 |
| CHEMBL203321 | BRINCIDOFOVIR | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL206291 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL286534 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL5314375 | CIDOFOVIR | EC50 | = | 30700.0 | nM | 4.51 |