Assay Detail
Binding
CHEMBL860877
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant Escherichia coli DXR
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
1-deoxy-D-xylulose 5-phosphate reductoisomerase (CHEMBL4091) ↗| Type | SINGLE PROTEIN |
| Organism | Escherichia coli K-12 |
Publication
Synthesis of alpha-substituted fosmidomycin analogues as highly potent Plasmodium falciparum growth inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.92 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL205338 | FR-900098 | — | 1 | 7.52 |
| CHEMBL203125 | FOSMIDOMYCIN | 3.0 | 1 | 7.52 |
| CHEMBL204106 | — | — | 1 | 7.23 |
| CHEMBL206189 | — | — | 1 | 7.00 |
| CHEMBL204107 | — | — | 1 | 6.92 |
| CHEMBL205339 | — | — | 1 | 6.81 |
| CHEMBL205052 | — | — | 1 | 6.51 |
| CHEMBL205053 | — | — | 1 | 6.40 |
| CHEMBL380142 | — | — | 1 | 6.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL205338 | FR-900098 | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL203125 | FOSMIDOMYCIN | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL204106 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL206189 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL204107 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL205339 | — | IC50 | = | 156.0 | nM | 6.81 |
| CHEMBL205052 | — | IC50 | = | 311.0 | nM | 6.51 |
| CHEMBL205053 | — | IC50 | = | 396.0 | nM | 6.40 |
| CHEMBL380142 | — | IC50 | = | 459.0 | nM | 6.34 |