Assay Detail
Functional
CHEMBL860995
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ER beta-mediated transactivation of ERE in HeLa cell luciferase assay at 10 uM
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and characterization of 3-arylquinazolinone and 3-arylquinazolinethione derivatives as selective estrogen receptor beta modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 30 | 5.69 | 9.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL135 | ESTRADIOL | 4.0 | 1 | 9.23 |
| CHEMBL1405 | ESTRONE | 4.0 | 1 | 6.78 |
| CHEMBL207101 | — | — | 1 | 6.11 |
| CHEMBL44 | GENISTEIN | 2.0 | 1 | 6.02 |
| CHEMBL206349 | — | — | 1 | 6.01 |
| CHEMBL202996 | THIOGENISTEIN | — | 1 | 5.95 |
| CHEMBL377083 | — | — | 1 | 5.94 |
| CHEMBL206131 | — | — | 1 | 5.85 |
| CHEMBL205920 | — | — | 1 | 5.83 |
| CHEMBL379889 | — | — | 1 | 5.78 |
| CHEMBL206137 | — | — | 1 | 5.62 |
| CHEMBL206336 | — | — | 1 | 5.62 |
| CHEMBL208324 | — | — | 1 | 5.55 |
| CHEMBL205398 | — | — | 1 | 5.54 |
| CHEMBL206764 | — | — | 1 | 5.51 |
| CHEMBL206648 | — | — | 1 | 5.50 |
| CHEMBL382698 | — | — | 1 | 5.37 |
| CHEMBL379252 | — | — | 1 | 5.34 |
| CHEMBL203351 | — | — | 1 | 5.34 |
| CHEMBL205249 | — | — | 1 | 5.33 |
| CHEMBL203724 | — | — | 1 | 5.31 |
| CHEMBL203330 | — | — | 1 | 5.29 |
| CHEMBL203283 | — | — | 1 | 5.28 |
| CHEMBL205395 | — | — | 1 | 5.08 |
| CHEMBL206773 | — | — | 1 | 5.03 |
| CHEMBL202894 | — | — | 1 | 5.03 |
| CHEMBL381720 | — | — | 1 | 5.03 |
| CHEMBL202738 | — | — | 1 | 5.00 |
| CHEMBL382786 | — | — | 1 | - |
| CHEMBL377293 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL135 | ESTRADIOL | EC50 | = | 0.59 | nM | 9.23 |
| CHEMBL1405 | ESTRONE | EC50 | = | 166.0 | nM | 6.78 |
| CHEMBL207101 | — | EC50 | = | 776.0 | nM | 6.11 |
| CHEMBL44 | GENISTEIN | EC50 | = | 956.0 | nM | 6.02 |
| CHEMBL206349 | — | EC50 | = | 983.0 | nM | 6.01 |
| CHEMBL202996 | THIOGENISTEIN | EC50 | = | 1125.0 | nM | 5.95 |
| CHEMBL377083 | — | EC50 | = | 1143.0 | nM | 5.94 |
| CHEMBL206131 | — | EC50 | = | 1427.0 | nM | 5.85 |
| CHEMBL205920 | — | EC50 | = | 1462.0 | nM | 5.83 |
| CHEMBL379889 | — | EC50 | = | 1669.0 | nM | 5.78 |
| CHEMBL206137 | — | EC50 | = | 2406.0 | nM | 5.62 |
| CHEMBL206336 | — | EC50 | = | 2392.0 | nM | 5.62 |
| CHEMBL208324 | — | EC50 | = | 2793.0 | nM | 5.55 |
| CHEMBL205398 | — | EC50 | = | 2918.0 | nM | 5.54 |
| CHEMBL206764 | — | EC50 | = | 3112.0 | nM | 5.51 |
| CHEMBL206648 | — | EC50 | = | 3143.0 | nM | 5.50 |
| CHEMBL382698 | — | EC50 | = | 4261.0 | nM | 5.37 |
| CHEMBL379252 | — | EC50 | = | 4576.0 | nM | 5.34 |
| CHEMBL203351 | — | EC50 | = | 4521.0 | nM | 5.34 |
| CHEMBL205249 | — | EC50 | = | 4624.0 | nM | 5.33 |
| CHEMBL203724 | — | EC50 | = | 4859.0 | nM | 5.31 |
| CHEMBL203330 | — | EC50 | = | 5137.0 | nM | 5.29 |
| CHEMBL203283 | — | EC50 | = | 5305.0 | nM | 5.28 |
| CHEMBL205395 | — | EC50 | = | 8317.0 | nM | 5.08 |
| CHEMBL206773 | — | EC50 | = | 9268.0 | nM | 5.03 |
| CHEMBL202894 | — | EC50 | = | 9317.0 | nM | 5.03 |
| CHEMBL381720 | — | EC50 | = | 9344.0 | nM | 5.03 |
| CHEMBL202738 | — | EC50 | = | 10082.0 | nM | 5.00 |
| CHEMBL382786 | — | EC50 | - | — | - | |
| CHEMBL377293 | — | EC50 | - | — | - |