Assay Detail
Binding
CHEMBL861138
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Inhibition of [3H]MK-801 binding to rat NMDA receptor
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Polyamines and the NMDA receptor: modifying intrinsic activities with aromatic substituents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 4.85 | 5.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL263511 | — | — | 1 | 5.41 |
| CHEMBL210939 | — | — | 1 | 5.36 |
| CHEMBL209931 | — | — | 1 | 5.33 |
| CHEMBL210619 | — | — | 1 | 5.21 |
| CHEMBL81614 | — | — | 1 | 5.21 |
| CHEMBL86096 | — | — | 1 | 5.13 |
| CHEMBL86281 | — | — | 1 | 5.08 |
| CHEMBL208663 | — | — | 1 | 5.06 |
| CHEMBL61691 | — | — | 1 | 5.04 |
| CHEMBL82641 | — | — | 1 | 5.02 |
| CHEMBL298628 | — | — | 1 | 5.01 |
| CHEMBL1161842 | — | — | 1 | 4.95 |
| CHEMBL1161844 | — | — | 1 | 4.89 |
| CHEMBL85189 | — | — | 1 | 4.88 |
| CHEMBL382900 | — | — | 1 | 4.85 |
| CHEMBL378650 | — | — | 1 | 4.85 |
| CHEMBL209403 | — | — | 1 | 4.84 |
| CHEMBL210338 | — | — | 1 | 4.76 |
| CHEMBL418644 | — | — | 1 | 4.75 |
| CHEMBL85779 | — | — | 1 | 4.59 |
| CHEMBL62048 | — | — | 1 | 4.57 |
| CHEMBL58084 | — | — | 1 | 4.42 |
| CHEMBL207249 | — | — | 1 | 4.35 |
| CHEMBL210566 | — | — | 1 | 4.25 |
| CHEMBL377977 | — | — | 1 | 4.24 |
| CHEMBL378890 | — | — | 1 | 4.09 |
| CHEMBL208700 | — | — | 1 | - |
| CHEMBL58301 | — | — | 1 | - |
| CHEMBL210944 | — | — | 1 | - |
| CHEMBL209126 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL263511 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL210939 | — | IC50 | = | 4370.0 | nM | 5.36 |
| CHEMBL209931 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL210619 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL81614 | — | IC50 | = | 6120.0 | nM | 5.21 |
| CHEMBL86096 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL86281 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL208663 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL61691 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL82641 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL298628 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL1161842 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL1161844 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL85189 | — | IC50 | = | 13100.0 | nM | 4.88 |
| CHEMBL378650 | — | IC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL382900 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL209403 | — | IC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL210338 | — | IC50 | = | 17200.0 | nM | 4.76 |
| CHEMBL418644 | — | IC50 | = | 17600.0 | nM | 4.75 |
| CHEMBL85779 | — | IC50 | = | 25600.0 | nM | 4.59 |
| CHEMBL62048 | — | IC50 | = | 26700.0 | nM | 4.57 |
| CHEMBL58084 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL207249 | — | IC50 | = | 44600.0 | nM | 4.35 |
| CHEMBL210566 | — | IC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL377977 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL378890 | — | IC50 | = | 82000.0 | nM | 4.09 |
| CHEMBL208700 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL58301 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL210944 | — | IC50 | = | 182000.0 | nM | - |
| CHEMBL209126 | — | IC50 | = | 6677000.0 | nM | - |
| CHEMBL210734 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL211029 | — | IC50 | = | 103000.0 | nM | - |
| CHEMBL210576 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL85964 | — | IC50 | > | 300000.0 | nM | - |