Assay Detail
Binding
CHEMBL861140
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Inhibition of DNA polymerase alpha
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
DNA polymerase alpha catalytic subunit (CHEMBL1828) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthetic analogues of the manzamenones and plakoridines which inhibit DNA polymerase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.13 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL380892 | — | — | 1 | 5.72 |
| CHEMBL210047 | — | — | 1 | 5.72 |
| CHEMBL449712 | — | — | 1 | 5.64 |
| CHEMBL210096 | — | — | 1 | 5.48 |
| CHEMBL380026 | — | — | 1 | 5.46 |
| CHEMBL425779 | E-ENEDIONE | — | 1 | 5.43 |
| CHEMBL366792 | UNTENONE A | — | 1 | 5.37 |
| CHEMBL207651 | — | — | 1 | 5.16 |
| CHEMBL381375 | — | — | 1 | 5.10 |
| CHEMBL437883 | — | — | 1 | 5.05 |
| CHEMBL208804 | — | — | 1 | 4.71 |
| CHEMBL379409 | — | — | 1 | 4.70 |
| CHEMBL437310 | — | — | 1 | 4.68 |
| CHEMBL377599 | — | — | 1 | 4.60 |
| CHEMBL210842 | PLAKEVULIN A | — | 1 | 4.18 |
| CHEMBL207165 | — | — | 1 | - |
| CHEMBL210764 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL380892 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL210047 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL449712 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL210096 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL380026 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL425779 | E-ENEDIONE | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL366792 | UNTENONE A | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL207651 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL381375 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL437883 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL208804 | — | IC50 | = | 19700.0 | nM | 4.71 |
| CHEMBL379409 | — | IC50 | = | 19900.0 | nM | 4.70 |
| CHEMBL437310 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL377599 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL210842 | PLAKEVULIN A | IC50 | = | 66000.0 | nM | 4.18 |
| CHEMBL207165 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL210764 | — | IC50 | > | 50000.0 | nM | - |