Compound Detail
CHEMBL210842
PLAKEVULIN A Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL210842 |
| Name | PLAKEVULIN A |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SOLXJOFQECGRPS-FUDKSRODSA-N |
4
Targets
8
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names
Molecular Properties
382.6
MW (Da)
5.31
ALogP
4
HBA
2
HBD
66.8
PSA (Ų)
0.22
QED
1
Ro5 Violations
16
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 8 meas. best 5.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| HL-60 CHEMBL383 | IC50 | 5.7 | 5.64 | 2020.0 | 2 |
| HeLa CHEMBL399 | IC50 | 4.94 | 4.94 | 11500.0 | 1 |
| MC3T3-E1 CHEMBL4296463 | IC50 | 4.91 | 4.91 | 12380.0 | 1 |
| DNA polymerase alpha catalytic subunit CHEMBL1828 | IC50 | 4.18 | 4.18 | 66000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| HL-60 | IC50 | = | 2020.0 | nM | 5.7 | Cytotoxicity against human HL-60 cells assessed as inhibition of cell viability ... | 38996938 |
| HL-60 | IC50 | = | 2630.0 | nM | 5.58 | Cytotoxicity against human HL-60 cells assessed as inhibition of cell viability ... | 38996938 |
| HeLa | IC50 | = | 11500.0 | nM | 4.94 | Cytotoxicity against human HeLa cells assessed as inhibition of cell viability i... | 38996938 |
| MC3T3-E1 | IC50 | = | 12380.0 | nM | 4.91 | Cytotoxicity against mouse MC3T3-E1 cells assessed as inhibition of cell viabili... | 38996938 |
| DNA polymerase alpha catalytic subunit | IC50 | = | 66000.0 | nM | 4.18 | Inhibition of DNA polymerase alpha | 16563761 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38996938 | 10.1016/j.bmcl.2024.129886 | HL-60 | 5 |
| 38996938 | 10.1016/j.bmcl.2024.129886 | Unchecked | 2 |
| 16563761 | 10.1016/j.bmcl.2006.03.005 | DNA polymerase alpha catalytic subunit | 1 |
| 16563761 | 10.1016/j.bmcl.2006.03.005 | DNA polymerase beta | 1 |
| 38996938 | 10.1016/j.bmcl.2024.129886 | HeLa | 1 |
| 38996938 | 10.1016/j.bmcl.2024.129886 | MC3T3-E1 | 1 |
| 38996938 | 10.1016/j.bmcl.2024.129886 | MRC5 | 1 |
| 38996938 | 10.1016/j.bmcl.2024.129886 | DNA polymerase beta | 1 |
Data from ChEMBL 36 via Core Engine