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Target Snapshot

CHEMBL4296463 Target Snapshot

MC3T3-E1 · CELL-LINE · Mus musculus

142Compounds
157Assays
1Approved Drugs
52.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats MC3T3-E1 as ChEMBL target CHEMBL4296463. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
MC3T3-E1
CELL-LINE · Mus musculus
As of 2026-09-14
ChEMBL target ID
CHEMBL4296463
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether MC3T3-E1 still has a stable protein naming contract across sources.

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Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelMC3T3-E1
UniProt AccessionN/A

MC3T3-E1

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as MC3T3-E1.

Review nameMC3T3-E1
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

IC5022.0
EC5030.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL409538 7.52 EC50 30.0 Preclinical
CHEMBL411091 7.52 EC50 30.0 Preclinical
CHEMBL476459 7.22 EC50 60.0 Preclinical
CHEMBL515779 7.05 EC50 90.0 Preclinical
CHEMBL476073 7.0 EC50 100.0 Preclinical
CHEMBL478903 6.39 EC50 410.0 Preclinical
CHEMBL852 6.17 IC50 680.0 Approved
CHEMBL5219154 6.1 IC50 790.0 Preclinical
CHEMBL476074 5.3 EC50 5000.0 Preclinical
CHEMBL210842 4.91 IC50 12380.0 Preclinical
Distribution

pChEMBL Value Distribution

1
5.0
0
5.5
5
6.0
4
6.5
12
7.0
5
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

MELPHALAN
CHEMBL852
Approved 1964
Assay Landscape

Assay Landscape

157
Total Assays
13
Tested Compounds
3
Assay Types
Functional — 143 assays, 13 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 143 13 6.8
ADME — 9 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 9 0
Toxicity — 5 assays, 7 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 5 7 4.1

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine