Assay Detail
Binding
CHEMBL861245
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of (+/-)-[3H]epibatidine from muscle type nAChR of Torpedo californica in hepes buffer
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Torpedo californica |
| Tissue | Muscle tissue |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
6H,13H-Pyrazino[1,2-a;4,5-a']diindole analogs: probing the pharmacophore for allosteric ligands of muscarinic M2 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.76 | 6.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL382243 | — | — | 1 | 6.48 |
| CHEMBL206666 | — | — | 1 | 6.26 |
| CHEMBL607178 | DIALLYLCARACURIE V | — | 1 | 5.82 |
| CHEMBL607179 | DIMETHYLCARACURIE V | — | 1 | 5.28 |
| CHEMBL203627 | — | — | 1 | 4.97 |
| CHEMBL380352 | CARACURINE V | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL382243 | — | Ki | = | 331.13 | nM | 6.48 |
| CHEMBL206666 | — | Ki | = | 549.54 | nM | 6.26 |
| CHEMBL607178 | DIALLYLCARACURIE V | Ki | = | 1513.56 | nM | 5.82 |
| CHEMBL607179 | DIMETHYLCARACURIE V | Ki | = | 5248.07 | nM | 5.28 |
| CHEMBL203627 | — | Ki | = | 10715.19 | nM | 4.97 |
| CHEMBL380352 | CARACURINE V | Ki | < | 100000.0 | nM | - |