Assay Detail
Functional
CHEMBL861278
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effect on blockade of Kv1.5 channel
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Potassium voltage-gated channel subfamily A member 5 (CHEMBL4306) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A new class of blockers of the voltage-gated potassium channel Kv1.3 via modification of the 4- or 7-position of khellinone.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 5.84 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL382154 | — | — | 1 | 6.16 |
| CHEMBL426482 | — | — | 1 | 6.05 |
| CHEMBL203909 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL382154 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL426482 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL203909 | — | EC50 | = | 5000.0 | nM | 5.30 |