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Compound Detail

CHEMBL203909

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CC(=O)c1c(O)c(OCc2ccccc2)c2occc2c1OCc1ccccc1

Basic Information

ChEMBL ID CHEMBL203909
Phase Preclinical
Structure Type MOL
InChI Key LLIUIMCUXHPION-UHFFFAOYSA-N
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

388.4
MW (Da)
5.50
ALogP
5
HBA
1
HBD
68.9
PSA (Ų)
0.42
QED
1
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C24H20O5
MW 388.42
Aromatic Rings 4
Heavy Atoms 29
NP-Likeness 0.64

Activity Summary

EC50 4 meas. best 5.92

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Potassium voltage-gated channel subfamily A member 3
CHEMBL4818
EC50 5.92 5.92 1200.0 1
Potassium voltage-gated channel subfamily A member 5
CHEMBL4306
EC50 5.3 5.3 5000.0 1
Potassium voltage-gated channel subfamily A member 1
CHEMBL2309
EC50 5.16 5.16 7000.0 1
Potassium voltage-gated channel subfamily A member 2
CHEMBL2086
EC50 5.0 5.0 10000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
16480279 10.1021/jm050839v Potassium voltage-gated channel subfamily A member 3 1
16480279 10.1021/jm050839v Potassium voltage-gated channel subfamily A member 1 1
16480279 10.1021/jm050839v Potassium voltage-gated channel subfamily A member 2 1
16480279 10.1021/jm050839v Potassium voltage-gated channel subfamily A member 4 1
16480279 10.1021/jm050839v Potassium voltage-gated channel subfamily A member 5 1
16480279 10.1021/jm050839v Voltage-gated inwardly rectifying potassium channel KCNH2 1

Data from ChEMBL 36 via Core Engine