Assay Detail
Functional
CHEMBL861292
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Agonist activity at delta opioid receptor by inhibition of muscle contraction in electrically stimulated isolated mouse vas deferens
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Tissue | Vas deferens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design and synthesis of novel hydrazide-linked bifunctional peptides as delta/mu opioid receptor agonists and CCK-1/CCK-2 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.56 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL200199 | BIPHALIN | — | 1 | 8.57 |
| CHEMBL408889 | — | — | 1 | 8.29 |
| CHEMBL413644 | — | — | 1 | 7.62 |
| CHEMBL412331 | — | — | 1 | 7.58 |
| CHEMBL375412 | — | — | 1 | 7.58 |
| CHEMBL407057 | — | — | 1 | 7.54 |
| CHEMBL442483 | — | — | 1 | 7.44 |
| CHEMBL408832 | — | — | 1 | 7.42 |
| CHEMBL374325 | — | — | 1 | 7.38 |
| CHEMBL438739 | — | — | 1 | 7.08 |
| CHEMBL405192 | — | — | 1 | 6.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL200199 | BIPHALIN | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL408889 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL413644 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL412331 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL375412 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL407057 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL442483 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL408832 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL374325 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL438739 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL405192 | — | IC50 | = | 230.0 | nM | 6.64 |