Assay Detail
Binding
CHEMBL861310
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Inhibition of JNK3-mediated ATF2 phosphorylation
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.86 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL378627 | — | — | 1 | 7.75 |
| CHEMBL210618 | — | — | 1 | 7.28 |
| CHEMBL210928 | — | — | 1 | 7.21 |
| CHEMBL210963 | — | — | 1 | 7.14 |
| CHEMBL208637 | — | — | 1 | 6.28 |
| CHEMBL210032 | — | — | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL378627 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL210618 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL210928 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL210963 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL208637 | — | Ki | = | 520.0 | nM | 6.28 |
| CHEMBL210032 | — | Ki | = | 3300.0 | nM | 5.48 |