Assay Detail
Binding
CHEMBL861320
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Inhibition of Akt1 at 5 uM ATP
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
RAC-alpha serine/threonine-protein kinase (CHEMBL4282) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Isoquinoline-pyridine-based protein kinase B/Akt antagonists: SAR and in vivo antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.21 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL207544 | — | — | 1 | 9.10 |
| CHEMBL378843 | — | — | 1 | 8.82 |
| CHEMBL378963 | — | — | 1 | 8.74 |
| CHEMBL209513 | — | — | 1 | 8.70 |
| CHEMBL383264 | — | — | 1 | 8.70 |
| CHEMBL210390 | — | — | 1 | 8.47 |
| CHEMBL210246 | — | — | 1 | 8.46 |
| CHEMBL379209 | — | — | 1 | 8.34 |
| CHEMBL210089 | — | — | 1 | 7.92 |
| CHEMBL380196 | — | — | 1 | 7.82 |
| CHEMBL377764 | — | — | 1 | 7.66 |
| CHEMBL378211 | — | — | 1 | 7.25 |
| CHEMBL210333 | — | — | 1 | 7.24 |
| CHEMBL378116 | — | — | 1 | 7.08 |
| CHEMBL209564 | — | — | 1 | 6.91 |
| CHEMBL206924 | — | — | 1 | 6.84 |
| CHEMBL208962 | — | — | 1 | 6.80 |
| CHEMBL378714 | — | — | 1 | 6.75 |
| CHEMBL210093 | — | — | 1 | 6.64 |
| CHEMBL210544 | — | — | 1 | 6.52 |
| CHEMBL210783 | — | — | 1 | 6.39 |
| CHEMBL381273 | — | — | 1 | 6.19 |
| CHEMBL210628 | — | — | 1 | 6.16 |
| CHEMBL208014 | — | — | 1 | 6.11 |
| CHEMBL208961 | — | — | 1 | 6.00 |
| CHEMBL207545 | — | — | 1 | 5.91 |
| CHEMBL207215 | — | — | 1 | 5.91 |
| CHEMBL210337 | — | — | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL207544 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL378843 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL378963 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL209513 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL383264 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL210390 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL210246 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL379209 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL210089 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL380196 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL377764 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL378211 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL210333 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL378116 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL209564 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL206924 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL208962 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL378714 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL210093 | — | IC50 | = | 227.0 | nM | 6.64 |
| CHEMBL210544 | — | IC50 | = | 305.0 | nM | 6.52 |
| CHEMBL210783 | — | IC50 | = | 407.0 | nM | 6.39 |
| CHEMBL381273 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL210628 | — | IC50 | = | 697.0 | nM | 6.16 |
| CHEMBL208014 | — | IC50 | = | 778.0 | nM | 6.11 |
| CHEMBL208961 | — | IC50 | = | 995.0 | nM | 6.00 |
| CHEMBL207545 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL207215 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL210337 | — | IC50 | = | 39500.0 | nM | 4.40 |