Assay Detail
Functional
CHEMBL861331
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GSK3 phosphorylation
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
RAC-alpha serine/threonine-protein kinase (CHEMBL4282) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Isoquinoline-pyridine-based protein kinase B/Akt antagonists: SAR and in vivo antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.79 | 6.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL210390 | — | — | 1 | 6.03 |
| CHEMBL383264 | — | — | 1 | 5.82 |
| CHEMBL378963 | — | — | 1 | 5.52 |
| CHEMBL210246 | — | — | 1 | - |
| CHEMBL207544 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL210390 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL383264 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL378963 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL210246 | — | IC50 | - | — | - | |
| CHEMBL207544 | — | IC50 | - | — | - |