Assay Detail
Binding
CHEMBL861434
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]SCH 23390 from D1 dopamine receptor
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Dopamine/serotonin receptor ligands. 12(1): SAR studies on hexahydro-dibenz[d,g]azecines lead to 4-chloro-7-methyl-5,6,7,8,9,14-hexahydrodibenz[d,g]azecin-3-ol, the first picomolar D5-selective dopamine-receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 8.32 | 9.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL201170 | — | — | 1 | 9.41 |
| CHEMBL380464 | — | — | 1 | 9.34 |
| CHEMBL203637 | — | — | 1 | 9.08 |
| CHEMBL441618 | — | — | 1 | 8.72 |
| CHEMBL381936 | — | — | 1 | 8.70 |
| CHEMBL203047 | — | — | 1 | 8.51 |
| CHEMBL383451 | — | — | 1 | 8.49 |
| CHEMBL379662 | — | — | 1 | 8.12 |
| CHEMBL203689 | — | — | 1 | 8.06 |
| CHEMBL382010 | — | — | 1 | 8.05 |
| CHEMBL204065 | — | — | 1 | 8.03 |
| CHEMBL204098 | — | — | 1 | 8.03 |
| CHEMBL203734 | — | — | 1 | 7.60 |
| CHEMBL380330 | — | — | 1 | 7.54 |
| CHEMBL381946 | — | — | 1 | 7.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL201170 | — | Ki | = | 0.39 | nM | 9.41 |
| CHEMBL380464 | — | Ki | = | 0.46 | nM | 9.34 |
| CHEMBL203637 | — | Ki | = | 0.83 | nM | 9.08 |
| CHEMBL441618 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL381936 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL203047 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL383451 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL379662 | — | Ki | = | 7.6 | nM | 8.12 |
| CHEMBL203689 | — | Ki | = | 8.7 | nM | 8.06 |
| CHEMBL382010 | — | Ki | = | 8.9 | nM | 8.05 |
| CHEMBL204065 | — | Ki | = | 9.4 | nM | 8.03 |
| CHEMBL204098 | — | Ki | = | 9.3 | nM | 8.03 |
| CHEMBL203734 | — | Ki | = | 25.3 | nM | 7.60 |
| CHEMBL380330 | — | Ki | = | 28.5 | nM | 7.54 |
| CHEMBL381946 | — | Ki | = | 82.0 | nM | 7.09 |