Assay Detail
Functional
CHEMBL861469
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Antiproliferative activity against human prostate tumor cell line LnCAP
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LNCaP |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
(6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines: platelet-derived growth factor receptor tyrosine kinase inhibitors with broad antiproliferative activity against tumor cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.04 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL331760 | — | — | 1 | 9.00 |
| CHEMBL120862 | — | — | 1 | 8.70 |
| CHEMBL120634 | — | — | 1 | 8.30 |
| CHEMBL120077 | — | — | 1 | 8.05 |
| CHEMBL184948 | — | — | 1 | 6.59 |
| CHEMBL432219 | — | — | 1 | 6.22 |
| CHEMBL121161 | — | — | 1 | 5.92 |
| CHEMBL371910 | — | — | 1 | 5.77 |
| CHEMBL371949 | — | — | 1 | 4.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL331760 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL120862 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL120634 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL120077 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL184948 | — | IC50 | = | 255.0 | nM | 6.59 |
| CHEMBL432219 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL121161 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL371910 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL371949 | — | IC50 | = | 14370.0 | nM | 4.84 |