Assay Detail
Functional
CHEMBL861474
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Antiproliferative activity against human glioma tumor cell line U87MG
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-87MG ATCC |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
(6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines: platelet-derived growth factor receptor tyrosine kinase inhibitors with broad antiproliferative activity against tumor cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.73 | 4.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL120077 | — | — | 1 | 4.89 |
| CHEMBL432219 | — | — | 1 | 4.68 |
| CHEMBL200735 | — | — | 1 | 4.62 |
| CHEMBL121161 | — | — | 1 | - |
| CHEMBL371949 | — | — | 1 | - |
| CHEMBL371910 | — | — | 1 | - |
| CHEMBL120634 | — | — | 1 | - |
| CHEMBL331760 | — | — | 1 | - |
| CHEMBL120862 | — | — | 1 | - |
| CHEMBL184948 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL120077 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL432219 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL200735 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL121161 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL371949 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL371910 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL120634 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL331760 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL120862 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL184948 | — | IC50 | > | 100000.0 | nM | - |