Assay Detail
Functional
CHEMBL861568
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Inhibitory activity against TGF-beta-stimulated proliferation in NIH3T3 cells
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | NIH3T3 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Dihydropyrrolopyrazole transforming growth factor-beta type I receptor kinase domain inhibitors: a novel benzimidazole series with selectivity versus transforming growth factor-beta type II receptor kinase and mixed lineage kinase-7.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.53 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL204170 | — | — | 1 | 7.50 |
| CHEMBL382838 | — | — | 1 | 7.38 |
| CHEMBL261454 | — | — | 1 | 7.09 |
| CHEMBL204966 | — | — | 1 | 7.02 |
| CHEMBL441176 | — | — | 1 | 6.86 |
| CHEMBL377711 | — | — | 1 | 6.82 |
| CHEMBL206233 | — | — | 1 | 6.60 |
| CHEMBL381532 | — | — | 1 | 6.56 |
| CHEMBL203791 | — | — | 1 | 6.56 |
| CHEMBL204063 | — | — | 1 | 6.43 |
| CHEMBL203619 | — | — | 1 | 6.43 |
| CHEMBL378167 | — | — | 1 | 6.07 |
| CHEMBL204139 | — | — | 1 | 6.06 |
| CHEMBL202730 | — | — | 1 | 6.00 |
| CHEMBL203214 | — | — | 1 | 5.79 |
| CHEMBL204158 | — | — | 1 | 5.33 |
| CHEMBL202625 | — | — | 1 | - |
| CHEMBL427211 | — | — | 1 | - |
| CHEMBL377717 | — | — | 1 | - |
| CHEMBL204061 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL204170 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL382838 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL261454 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL204966 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL441176 | — | IC50 | = | 139.0 | nM | 6.86 |
| CHEMBL377711 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL206233 | — | IC50 | = | 249.0 | nM | 6.60 |
| CHEMBL381532 | — | IC50 | = | 277.0 | nM | 6.56 |
| CHEMBL203791 | — | IC50 | = | 274.0 | nM | 6.56 |
| CHEMBL204063 | — | IC50 | = | 371.0 | nM | 6.43 |
| CHEMBL203619 | — | IC50 | = | 371.0 | nM | 6.43 |
| CHEMBL378167 | — | IC50 | = | 854.0 | nM | 6.07 |
| CHEMBL204139 | — | IC50 | = | 872.0 | nM | 6.06 |
| CHEMBL202730 | — | IC50 | = | 1001.0 | nM | 6.00 |
| CHEMBL203214 | — | IC50 | = | 1622.0 | nM | 5.79 |
| CHEMBL204158 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL202625 | — | IC50 | - | — | - | |
| CHEMBL427211 | — | IC50 | - | — | - | |
| CHEMBL377717 | — | IC50 | - | — | - | |
| CHEMBL204061 | — | IC50 | - | — | - |