Compound Detail
CHEMBL378167
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Basic Information
| ChEMBL ID | CHEMBL378167 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MRWVGMSSTRXBOX-UHFFFAOYSA-N |
4
Targets
6
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
412.5
MW (Da)
4.39
ALogP
6
HBA
0
HBD
51.8
PSA (Ų)
0.47
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 6 meas. best 6.65
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| TGF-beta receptor type-1 CHEMBL4439 | IC50 | 6.65 | 6.6233 | 226.0 | 3 |
| Unchecked CHEMBL612545 | IC50 | 6.07 | 6.07 | 854.0 | 1 |
| Mitogen-activated protein kinase kinase kinase 20 CHEMBL3886 | IC50 | 5.31 | 5.31 | 4880.0 | 1 |
| TGF-beta receptor type-2 CHEMBL4267 | IC50 | 4.96 | 4.96 | 10840.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| TGF-beta receptor type-1 | IC50 | = | 226.0 | nM | 6.65 | Inhibition of TGFbeta R1 induced transcriptional activation of p3TP-Lux in mink ... | 16539403 |
| TGF-beta receptor type-1 | IC50 | = | 246.0 | nM | 6.61 | Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cells | 16539403 |
| TGF-beta receptor type-1 | IC50 | = | 246.0 | nM | 6.61 | Inhibition of TGFR1 | 19640613 |
| Unchecked | IC50 | = | 854.0 | nM | 6.07 | Inhibitory activity against TGF-beta-stimulated proliferation in NIH3T3 cells | 16539403 |
| Mitogen-activated protein kinase kinase kinase 20 | IC50 | = | 4880.0 | nM | 5.31 | Inhibition of MLK7 | 16539403 |
| TGF-beta receptor type-2 | IC50 | = | 10840.0 | nM | 4.96 | Inhibition of recombinant human TGFbeta R2 expressed in Sf9 cells | 16539403 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16539403 | 10.1021/jm058209g | TGF-beta receptor type-1 | 2 |
| 16539403 | 10.1021/jm058209g | TGF-beta receptor type-2 | 1 |
| 16539403 | 10.1021/jm058209g | Mitogen-activated protein kinase kinase kinase 20 | 1 |
| 16539403 | 10.1021/jm058209g | Unchecked | 1 |
| 19640613 | 10.1016/j.ejmech.2009.07.008 | TGF-beta receptor type-1 | 1 |
Data from ChEMBL 36 via Core Engine