Assay Detail
Binding
CHEMBL861565
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Inhibition of MLK7
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Mitogen-activated protein kinase kinase kinase 20 (CHEMBL3886) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Dihydropyrrolopyrazole transforming growth factor-beta type I receptor kinase domain inhibitors: a novel benzimidazole series with selectivity versus transforming growth factor-beta type II receptor kinase and mixed lineage kinase-7.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.38 | 6.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL203619 | — | — | 1 | 6.15 |
| CHEMBL204170 | — | — | 1 | 5.88 |
| CHEMBL261454 | — | — | 1 | 5.85 |
| CHEMBL204966 | — | — | 1 | 5.63 |
| CHEMBL204063 | — | — | 1 | 5.55 |
| CHEMBL378167 | — | — | 1 | 5.31 |
| CHEMBL381532 | — | — | 1 | 5.07 |
| CHEMBL382838 | — | — | 1 | 4.80 |
| CHEMBL202730 | — | — | 1 | 4.80 |
| CHEMBL427211 | — | — | 1 | 4.78 |
| CHEMBL204158 | — | — | 1 | - |
| CHEMBL202625 | — | — | 1 | - |
| CHEMBL203214 | — | — | 1 | - |
| CHEMBL204139 | — | — | 1 | - |
| CHEMBL377711 | — | — | 1 | - |
| CHEMBL206233 | — | — | 1 | - |
| CHEMBL441176 | — | — | 1 | - |
| CHEMBL377717 | — | — | 1 | - |
| CHEMBL204061 | — | — | 1 | - |
| CHEMBL203791 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL203619 | — | IC50 | = | 708.0 | nM | 6.15 |
| CHEMBL204170 | — | IC50 | = | 1310.0 | nM | 5.88 |
| CHEMBL261454 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL204966 | — | IC50 | = | 2340.0 | nM | 5.63 |
| CHEMBL204063 | — | IC50 | = | 2810.0 | nM | 5.55 |
| CHEMBL378167 | — | IC50 | = | 4880.0 | nM | 5.31 |
| CHEMBL381532 | — | IC50 | = | 8480.0 | nM | 5.07 |
| CHEMBL382838 | — | IC50 | = | 15940.0 | nM | 4.80 |
| CHEMBL202730 | — | IC50 | = | 15880.0 | nM | 4.80 |
| CHEMBL427211 | — | IC50 | = | 16610.0 | nM | 4.78 |
| CHEMBL204158 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL202625 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL203214 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL204139 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL377711 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL206233 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL441176 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL377717 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL204061 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL203791 | — | IC50 | > | 20000.0 | nM | - |