Assay Detail
Binding
CHEMBL861669
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Increase in [3H]flunitrazepam binding to GABA-A receptor in mouse embryo cortical neurons
14
Total Activities
14
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
GABA-A receptor; anion channel (CHEMBL2094133) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Mus musculus |
Publication
Activity of B-nor analogues of neurosteroids on the GABA(A) receptor in primary neuronal cultures.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 10 | - | - |
| EC50 | 4 | 6.16 | 6.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL379949 | — | — | 1 | 6.61 |
| CHEMBL207538 | BREXANOLONE | 4.0 | 1 | 6.06 |
| CHEMBL210767 | — | — | 1 | 6.03 |
| CHEMBL210952 | ELTANOLONE | 2.0 | 1 | 5.93 |
| CHEMBL210387 | — | — | 1 | - |
| CHEMBL378742 | — | — | 1 | - |
| CHEMBL383839 | — | — | 1 | - |
| CHEMBL379786 | — | — | 1 | - |
| CHEMBL379583 | — | — | 1 | - |
| CHEMBL211043 | — | — | 1 | - |
| CHEMBL210998 | — | — | 1 | - |
| CHEMBL207412 | — | — | 1 | - |
| CHEMBL207079 | — | — | 1 | - |
| CHEMBL207302 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL379949 | — | EC50 | = | 245.47 | nM | 6.61 |
| CHEMBL207538 | BREXANOLONE | EC50 | = | 870.96 | nM | 6.06 |
| CHEMBL210767 | — | EC50 | = | 933.25 | nM | 6.03 |
| CHEMBL210952 | ELTANOLONE | EC50 | = | 1174.9 | nM | 5.93 |
| CHEMBL210387 | — | Activity | - | — | - | |
| CHEMBL378742 | — | Activity | - | — | - | |
| CHEMBL383839 | — | Activity | - | — | - | |
| CHEMBL379786 | — | Activity | - | — | - | |
| CHEMBL379583 | — | Activity | - | — | - | |
| CHEMBL211043 | — | Activity | - | — | - | |
| CHEMBL210998 | — | Activity | - | — | - | |
| CHEMBL207412 | — | Activity | - | — | - | |
| CHEMBL207079 | — | Activity | - | — | - | |
| CHEMBL207302 | — | Activity | - | — | - |