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Assay Detail

CHEMBL861697

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Functional
Antiproliferative activity against human HL60 cell line
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HL-60
Confidence 1 — Organism
Curated By Intermediate

Target

HL-60 (CHEMBL383)
Type CELL-LINE
Organism Homo sapiens

Publication

Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells.
Roberti M, Pizzirani D, Recanatini M, Simoni D, Grimaudo S, Di Cristina A, Abbadessa V, Gebbia N, Tolomeo M.
J Med Chem (2006) 49 : 3012 -3018
PubMed 16686543 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 22 4.90 5.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL207903 1 5.60
CHEMBL296411 TRISMETHOXYRESVERATROL 1 5.60
CHEMBL208098 1 5.46
CHEMBL207244 1 5.46
CHEMBL381164 1 5.32
CHEMBL207240 1 5.30
CHEMBL165 RESVERATROL 3.0 1 5.30
CHEMBL427392 1 5.16
CHEMBL379687 1 5.16
CHEMBL206049 1 5.05
CHEMBL362997 1 5.00
CHEMBL381734 1 4.96
CHEMBL206633 1 4.85
CHEMBL383273 1 4.70
CHEMBL175736 1 4.64
CHEMBL207941 1 4.57
CHEMBL197892 1 4.55
CHEMBL83527 PTEROSTILBENE 2.0 1 4.46
CHEMBL206919 1 4.30
CHEMBL194888 1 4.12
CHEMBL207826 1 4.12
CHEMBL207989 1 4.08

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL207903 IC50 = 2500.0 nM 5.60
CHEMBL296411 TRISMETHOXYRESVERATROL IC50 = 2500.0 nM 5.60
CHEMBL208098 IC50 = 3500.0 nM 5.46
CHEMBL207244 IC50 = 3500.0 nM 5.46
CHEMBL381164 IC50 = 4800.0 nM 5.32
CHEMBL207240 IC50 = 5000.0 nM 5.30
CHEMBL165 RESVERATROL IC50 = 5000.0 nM 5.30
CHEMBL427392 IC50 = 7000.0 nM 5.16
CHEMBL379687 IC50 = 7000.0 nM 5.16
CHEMBL206049 IC50 = 9000.0 nM 5.05
CHEMBL362997 IC50 = 10000.0 nM 5.00
CHEMBL381734 IC50 = 11000.0 nM 4.96
CHEMBL206633 IC50 = 14000.0 nM 4.85
CHEMBL383273 IC50 = 20000.0 nM 4.70
CHEMBL175736 IC50 = 23000.0 nM 4.64
CHEMBL207941 IC50 = 27000.0 nM 4.57
CHEMBL197892 IC50 = 28000.0 nM 4.55
CHEMBL83527 PTEROSTILBENE IC50 = 35000.0 nM 4.46
CHEMBL206919 IC50 = 50000.0 nM 4.30
CHEMBL194888 IC50 = 76000.0 nM 4.12
CHEMBL207826 IC50 = 75000.0 nM 4.12
CHEMBL207989 IC50 = 84000.0 nM 4.08