Assay Detail
Binding
CHEMBL861797
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Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in human brain
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel histamine H3 receptor antagonists based on the 4-[(1H-imidazol-4-yl)methyl]piperidine scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.96 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL373000 | — | — | 1 | 9.40 |
| CHEMBL371730 | — | — | 1 | 8.77 |
| CHEMBL200382 | — | — | 1 | 8.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL373000 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL371730 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL200382 | — | Ki | = | 1.9 | nM | 8.72 |