Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL861830

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against HIV1 replication in CEM cell line
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human immunodeficiency virus 1
Cell Type CCRF-CEM
Confidence 1 — Organism
Curated By Expert

Target

Human immunodeficiency virus 1 (CHEMBL378)
Type ORGANISM
Organism Human immunodeficiency virus 1

Publication

Abacavir prodrugs: microwave-assisted synthesis and their evaluation of anti-HIV activities.
Sriram D, Yogeeswari P, Myneedu NS, Saraswat V.
Bioorg Med Chem Lett (2006) 16 : 2127 -2129
PubMed 16458506 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 12 6.05 7.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL426855 1 7.30
CHEMBL205275 1 7.22
CHEMBL206008 1 6.44
CHEMBL203074 1 6.32
CHEMBL383195 1 6.28
CHEMBL377530 1 5.92
CHEMBL1380 ABACAVIR 4.0 1 5.80
CHEMBL208388 1 5.72
CHEMBL206958 1 5.68
CHEMBL205343 1 5.43
CHEMBL379404 1 5.30
CHEMBL207417 1 5.21

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL426855 EC50 = 50.0 nM 7.30
CHEMBL205275 EC50 = 60.0 nM 7.22
CHEMBL206008 EC50 = 360.0 nM 6.44
CHEMBL203074 EC50 = 480.0 nM 6.32
CHEMBL383195 EC50 = 520.0 nM 6.28
CHEMBL377530 EC50 = 1200.0 nM 5.92
CHEMBL1380 ABACAVIR EC50 = 1600.0 nM 5.80
CHEMBL208388 EC50 = 1900.0 nM 5.72
CHEMBL206958 EC50 = 2100.0 nM 5.68
CHEMBL205343 EC50 = 3700.0 nM 5.43
CHEMBL379404 EC50 = 5000.0 nM 5.30
CHEMBL207417 EC50 = 6200.0 nM 5.21