Assay Detail
Binding
CHEMBL861908
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against VEGFR1 by HTRF assay
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Vascular endothelial growth factor receptor 1 (CHEMBL1868) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
N-(Aryl)-4-(azolylethyl)thiazole-5-carboxamides: novel potent inhibitors of VEGF receptors I and II.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 5.93 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL24828 | VANDETANIB | 4.0 | 1 | 7.00 |
| CHEMBL101253 | VATALANIB | 3.0 | 1 | 6.85 |
| CHEMBL202011 | — | — | 1 | 6.80 |
| CHEMBL153843 | — | — | 1 | 6.77 |
| CHEMBL205114 | — | — | 1 | 6.51 |
| CHEMBL383215 | — | — | 1 | 6.23 |
| CHEMBL202153 | — | — | 1 | 6.20 |
| CHEMBL202466 | — | — | 1 | 6.14 |
| CHEMBL202384 | — | — | 1 | 6.14 |
| CHEMBL370600 | — | — | 1 | 6.12 |
| CHEMBL379674 | — | — | 1 | 6.12 |
| CHEMBL201906 | — | — | 1 | 6.08 |
| CHEMBL202408 | — | — | 1 | 5.63 |
| CHEMBL382308 | — | — | 1 | 5.52 |
| CHEMBL201713 | — | — | 1 | 5.42 |
| CHEMBL203095 | — | — | 1 | 5.34 |
| CHEMBL380700 | — | — | 1 | 5.33 |
| CHEMBL202714 | — | — | 1 | 5.27 |
| CHEMBL202109 | — | — | 1 | 5.27 |
| CHEMBL201014 | — | — | 1 | 5.26 |
| CHEMBL201659 | — | — | 1 | 5.19 |
| CHEMBL203149 | — | — | 1 | 5.16 |
| CHEMBL202234 | — | — | 1 | - |
| CHEMBL381300 | — | — | 1 | - |
| CHEMBL205113 | — | — | 1 | - |
| CHEMBL377921 | — | — | 1 | - |
| CHEMBL202383 | — | — | 1 | - |
| CHEMBL201712 | — | — | 1 | - |
| CHEMBL424672 | — | — | 1 | - |
| CHEMBL382184 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL24828 | VANDETANIB | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL101253 | VATALANIB | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL202011 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL153843 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL205114 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL383215 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL202153 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL202466 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL202384 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL370600 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL379674 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL201906 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL202408 | — | IC50 | = | 2330.0 | nM | 5.63 |
| CHEMBL382308 | — | IC50 | = | 3020.0 | nM | 5.52 |
| CHEMBL201713 | — | IC50 | = | 3850.0 | nM | 5.42 |
| CHEMBL203095 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL380700 | — | IC50 | = | 4660.0 | nM | 5.33 |
| CHEMBL202714 | — | IC50 | = | 5420.0 | nM | 5.27 |
| CHEMBL202109 | — | IC50 | = | 5320.0 | nM | 5.27 |
| CHEMBL201014 | — | IC50 | = | 5460.0 | nM | 5.26 |
| CHEMBL201659 | — | IC50 | = | 6410.0 | nM | 5.19 |
| CHEMBL203149 | — | IC50 | = | 6850.0 | nM | 5.16 |
| CHEMBL383575 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL201303 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL425930 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL382647 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL203698 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL382184 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL424672 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL201712 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL202383 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL377921 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL205113 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL381300 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL202234 | — | IC50 | > | 10000.0 | nM | - |