Compound Detail
CHEMBL380700
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Basic Information
| ChEMBL ID | CHEMBL380700 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZWYIJBSDKBGWSF-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
323.4
MW (Da)
3.88
ALogP
4
HBA
1
HBD
54.9
PSA (Ų)
0.77
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.25
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 6.25 | 6.25 | 560.0 | 1 |
| Vascular endothelial growth factor receptor 1 CHEMBL1868 | IC50 | 5.33 | 5.33 | 4660.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 | IC50 | = | 560.0 | nM | 6.25 | Inhibitory activity against VEGFR2 by HTRF assay | 16275072 |
| Vascular endothelial growth factor receptor 1 | IC50 | = | 4660.0 | nM | 5.33 | Inhibitory activity against VEGFR1 by HTRF assay | 16275072 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16275072 | 10.1016/j.bmcl.2005.10.058 | Vascular endothelial growth factor receptor 2 | 2 |
| 16275072 | 10.1016/j.bmcl.2005.10.058 | Vascular endothelial growth factor receptor 1 | 1 |
Data from ChEMBL 36 via Core Engine