Assay Detail
Functional
CHEMBL861978
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Antiproliferative activity against human PC3 cell line
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Optimization of subsite binding to the beta5 subunit of the human 20S proteasome using vinyl sulfones and 2-keto-1,3,4-oxadiazoles: syntheses and cellular properties of potent, selective proteasome inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 6.10 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL207990 | EPOXOMYCIN | — | 1 | 9.00 |
| CHEMBL383674 | — | — | 1 | 6.70 |
| CHEMBL382203 | — | — | 1 | 6.70 |
| CHEMBL207591 | — | — | 1 | 6.43 |
| CHEMBL379772 | — | — | 1 | 6.35 |
| CHEMBL376815 | — | — | 1 | 6.30 |
| CHEMBL207016 | — | — | 1 | 6.30 |
| CHEMBL381735 | — | — | 1 | 6.26 |
| CHEMBL64925 | MG-132 | — | 1 | 6.22 |
| CHEMBL446443 | — | — | 1 | 6.22 |
| CHEMBL207403 | — | — | 1 | 6.10 |
| CHEMBL207336 | — | — | 1 | 5.76 |
| CHEMBL207162 | — | — | 1 | 5.70 |
| CHEMBL204946 | — | — | 1 | 5.62 |
| CHEMBL206206 | — | — | 1 | 5.52 |
| CHEMBL379669 | — | — | 1 | 5.52 |
| CHEMBL379771 | — | — | 1 | 5.49 |
| CHEMBL204992 | — | — | 1 | 5.40 |
| CHEMBL208015 | — | — | 1 | 5.19 |
| CHEMBL383529 | — | — | 1 | 5.12 |
| CHEMBL207196 | — | — | 1 | - |
| CHEMBL205757 | — | — | 1 | - |
| CHEMBL205687 | — | — | 1 | - |
| CHEMBL206413 | — | — | 1 | - |
| CHEMBL437115 | — | — | 1 | - |
| CHEMBL438612 | — | — | 1 | - |
| CHEMBL206001 | — | — | 1 | - |
| CHEMBL207669 | — | — | 1 | - |
| CHEMBL208372 | — | — | 1 | - |
| CHEMBL377532 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL207990 | EPOXOMYCIN | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL383674 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL382203 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL207591 | — | IC50 | = | 375.0 | nM | 6.43 |
| CHEMBL379772 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL376815 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL207016 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL381735 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL64925 | MG-132 | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL446443 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL207403 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL207336 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL207162 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL204946 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL206206 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL379669 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL379771 | — | IC50 | = | 3250.0 | nM | 5.49 |
| CHEMBL204992 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL208015 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL383529 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL207196 | — | IC50 | - | — | - | |
| CHEMBL205757 | — | IC50 | - | — | - | |
| CHEMBL205687 | — | IC50 | - | — | - | |
| CHEMBL206413 | — | IC50 | - | — | - | |
| CHEMBL437115 | — | IC50 | = | 3000000.0 | nM | - |
| CHEMBL438612 | — | IC50 | = | 5000000.0 | nM | - |
| CHEMBL206001 | — | IC50 | - | — | - | |
| CHEMBL207669 | — | IC50 | - | — | - | |
| CHEMBL208372 | — | IC50 | - | — | - | |
| CHEMBL377532 | — | IC50 | - | — | - |