Assay Detail
Binding
CHEMBL862013
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to Wistar rat benzodiazepine receptor
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
GABA-A receptor; anion channel (CHEMBL1907607) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Synthesis, pharmacology, and structure-activity relationships of novel imidazolones and pyrrolones as modulators of GABAA receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 39 | 5.94 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20042 | CGS-9896 | — | 1 | 8.62 |
| CHEMBL12 | DIAZEPAM | 4.0 | 1 | 8.17 |
| CHEMBL204205 | — | — | 1 | 7.17 |
| CHEMBL203572 | — | — | 1 | 7.05 |
| CHEMBL204755 | — | — | 1 | 6.85 |
| CHEMBL381174 | — | — | 1 | 6.46 |
| CHEMBL203651 | — | — | 1 | 6.36 |
| CHEMBL380524 | — | — | 1 | 6.31 |
| CHEMBL204027 | — | — | 1 | 6.03 |
| CHEMBL204040 | — | — | 1 | 5.98 |
| CHEMBL203853 | — | — | 1 | 5.95 |
| CHEMBL383127 | — | — | 1 | 5.69 |
| CHEMBL203217 | — | — | 1 | 5.51 |
| CHEMBL204553 | — | — | 1 | 5.49 |
| CHEMBL203902 | — | — | 1 | 5.48 |
| CHEMBL205164 | — | — | 1 | 5.48 |
| CHEMBL204091 | — | — | 1 | 5.37 |
| CHEMBL381915 | — | — | 1 | 5.36 |
| CHEMBL204240 | IMEPITOIN | -1.0 | 1 | 5.36 |
| CHEMBL203833 | — | — | 1 | 5.35 |
| CHEMBL206705 | — | — | 1 | 5.35 |
| CHEMBL413575 | — | — | 1 | 5.27 |
| CHEMBL382485 | — | — | 1 | 5.20 |
| CHEMBL204131 | — | — | 1 | 5.05 |
| CHEMBL204081 | — | — | 1 | 4.94 |
| CHEMBL206037 | — | — | 1 | 4.58 |
| CHEMBL19732 | CGS-8216 | — | 1 | - |
| CHEMBL204581 | — | — | 1 | - |
| CHEMBL3144798 | — | — | 1 | - |
| CHEMBL412630 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20042 | CGS-9896 | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL12 | DIAZEPAM | Ki | = | 6.8 | nM | 8.17 |
| CHEMBL204205 | — | Ki | = | 67.0 | nM | 7.17 |
| CHEMBL203572 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL204755 | — | Ki | = | 141.0 | nM | 6.85 |
| CHEMBL381174 | — | Ki | = | 344.0 | nM | 6.46 |
| CHEMBL203651 | — | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL380524 | — | Ki | = | 494.0 | nM | 6.31 |
| CHEMBL204027 | — | Ki | = | 938.0 | nM | 6.03 |
| CHEMBL204040 | — | Ki | = | 1040.0 | nM | 5.98 |
| CHEMBL203853 | — | Ki | = | 1120.0 | nM | 5.95 |
| CHEMBL383127 | — | Ki | = | 2050.0 | nM | 5.69 |
| CHEMBL203217 | — | Ki | = | 3060.0 | nM | 5.51 |
| CHEMBL204553 | — | Ki | = | 3260.0 | nM | 5.49 |
| CHEMBL205164 | — | Ki | = | 3320.0 | nM | 5.48 |
| CHEMBL203902 | — | Ki | = | 3290.0 | nM | 5.48 |
| CHEMBL204091 | — | Ki | = | 4290.0 | nM | 5.37 |
| CHEMBL381915 | — | Ki | = | 4340.0 | nM | 5.36 |
| CHEMBL204240 | IMEPITOIN | Ki | = | 4350.0 | nM | 5.36 |
| CHEMBL203833 | — | Ki | = | 4450.0 | nM | 5.35 |
| CHEMBL206705 | — | Ki | = | 4480.0 | nM | 5.35 |
| CHEMBL413575 | — | Ki | = | 5410.0 | nM | 5.27 |
| CHEMBL382485 | — | Ki | = | 6280.0 | nM | 5.20 |
| CHEMBL204131 | — | Ki | = | 8880.0 | nM | 5.05 |
| CHEMBL204081 | — | Ki | = | 11600.0 | nM | 4.94 |
| CHEMBL206037 | — | Ki | = | 26100.0 | nM | 4.58 |
| CHEMBL206448 | — | Ki | - | — | - | |
| CHEMBL383680 | — | Ki | - | — | - | |
| CHEMBL206338 | — | Ki | - | — | - | |
| CHEMBL383066 | — | Ki | - | — | - | |
| CHEMBL382483 | — | Ki | - | — | - | |
| CHEMBL440575 | — | Ki | - | — | - | |
| CHEMBL381072 | — | Ki | - | — | - | |
| CHEMBL203968 | — | Ki | - | — | - | |
| CHEMBL203708 | — | Ki | - | — | - | |
| CHEMBL412630 | — | Ki | - | — | - | |
| CHEMBL3144798 | — | Ki | - | — | - | |
| CHEMBL204581 | — | Ki | - | — | - | |
| CHEMBL19732 | CGS-8216 | Ki | - | — | - |